Identifying Genes - Polymorphic Markers
Professor Jonathan Finch describes one technique for identifying genes in rodents.
The way we go about identifying genes that contribute to quantitative variation in rodents primarily has involved, up to date at least, crosses between inbred strains - thatâ€™s to say, animals who are genetically identical - and tracking the segregation of genes using anonymous polymorphic markers. There have been a large number of approaches subsequent to that, but that remains the mainstay of identifying the chromosomal positions of those genes.
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Professor Jonathan Finch explains that the neurobiology of neuroticism is similar in humans and animal models.
Watch the animation to learn more about why genetic markers offer important clues in the hunt for genes.
Professor Jonathan Finch defines neuroticism, a measure of emotional stability that correlates with depression.
Evolutionary geneticist Michael Hammer speaks about the markers used to analyze DNA variation in the Y chromosome.
A single nucleotide polymorphism, or SNP, occurs when two individuals in the population differ by a single letter in the DNA sequence.
Locate a disease gene by screening for markers linked to the gene.
Doctor Thomas Insel makes the case for model animals with the power to see how candidate genes for human disorders could affect other systems.
Evidence in humans that a structured exercise training program increases neurogenesis.
By 1990, King had found a "landmark" that helped her fix the gene's position on a chromosome. This DNA marker was on chromosome 17, and was linked to breast cancer in a subset of the families she studied. She teamed up with Francis Collins in a race to f
Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.