Neuroticism in Animals
Professor Jonathan Finch explains that the neurobiology of neuroticism is similar in humans and animal models.
Well, animal models of anxiety are probably meaningful because it seems fairly unlikely that animals donâ€™t get frightened and the likelihood is they get frightened the same ways we do. We know, in fact, that the neurobiology of those two processes is fairly similar. And because there is a fairly large overlap between anxiety and depression in humans, we make the assumption, not entirely proven, that the same applies also in animals.
neuroticism, animal, model, neurobiology, jonathan, finch, anxiety, depression
Professor Jonathan Finch defines neuroticism, a measure of emotional stability that correlates with depression.
Professor Jonathan Finch describes one technique for identifying genes in rodents.
Doctor Daniel Pine introduces the diathesis-stress model for anxiety and depression. The model posits that stress combines with inherited factors to produce disorder.
Professor Bruce McEwen describes the interplay between reilience and stress, which can cause the brain to shrink or grow.
Professor Wayne Drevets explains that specific glial cells known as oligodendrocytes may be decreased in the brains of individuals who have bipolar disorder or major depressive disorder.
Professor Wayne Drevets discusses the amygdala, striatum, and prefrontal cortex as neural correlates of bipolar disorder. Mania and depression may link to the dopamine system.
Doctor Abraham Zangen discusses how transcranial magnetic stimulation (TMS) can stimulate different areas of the brain and treat depression.
Doctor Thomas Insel makes the case for model animals with the power to see how candidate genes for human disorders could affect other systems.
Doctor Daniel Pine estimates that approximately 30-50% of the risk for anxiety and depression is genetic. Genetic treatments are an exciting area of research currently.
Doctor Daniel Pine discusses explains that anxiety is more common in girls and women. Depression is also more common in women, but only after puberty. Anxiety may predict depression.