The early stages of the hunt for BRCA1, Mary-Claire King
Interviewee: Mary-Claire King. Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not. (DNAi Location: Applications > Genes and medicine > Gene hunting > Mary-Claire King > What she was looking for)
So what we were looking for was some fragment of DNA flagging some chromosome somewhere in the genome, that was shared by all of the cancer cases in the family, all of the women with cancer, and was not held by branches of the family where there had been few women with cancer.
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Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.
Mary-Claire King talks about testing for breast cancer.
Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mark Skolnick talks about the hunt for BRCA1.
Mary-Claire King recalls her reaction when she heard that the Skolnick team had successfully cloned BRCA1 and made it to the finish line first.
Mary-Claire King talks bout tedious process of early gene hunting.
MARY-CLAIRE KING (1946- )