Reaction to Myriad's announcement that BRCA1 had been found, Mary-Claire King
Interviewee: Mary-Claire King. Mary-Claire King recalls her reaction when she heard that the Skolnick team had successfully cloned BRCA1 and made it to the finish line first. (DNAi Location Applications > Genes and Medicine > Gene hunting > The finish line > Hearing BRCA1 had been cloned)
When I heard Myriad's announcement I was reading sequence. And I first heard it from a journalist who had, heard it from Myriad and I said I want to know, you know, what's the data. And the data was very quick in coming and of course we all knew the region so well that it, that we would be either very quickly convinced or it would be obvious immediately that they were wrong. And we were quickly convinced they were right, and all that played out within several hours. And I remember feeling, it's been found, gosh, now we can get on with it and try to go to the next step. And in the previous years I had anticipated that if some other group found it, that I would just be devastated. And when I learned that Myriad had, I kept waiting to feel devastated, and I never felt devastated.
mary claire king,brca1 gene,location applications,finish line,dnai,interviewee,previous years,genes,journalist,medicine
Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.
Mary-Claire King talks about testing for breast cancer.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Mark Skolnick talks about moving on after the discovery of BRCA1 to find and clone another gene associated with breast cancer, BRCA2.
MARY-CLAIRE KING (1946- )
Mary-Claire King talks bout tedious process of early gene hunting.