Testing for mutations in BRCA1, Mary-Claire King
Interviewee: Mary-Claire King. Mary-Claire King, geneticist and gene-mapper. (DNAi Location: Genome >Tour > Genome spots > Breast cancer (BRCA1) > Testing for breast cancer)
Well at present with BRCA1 and BRCA2, where we stand is that it's possible to identify for some women in families with very large numbers of breast and ovarian cancers, whether they are at risk or not. That is to say, that if a woman has a conventional sort of mutation in one of these genes, it can be found. And the great majority of, of such mutations are found by commercial testing.
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Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
BRCA2, on chromosome 13, is one of the genes associated with hereditary breast cancer
BRCA1, on chromosome 17, is one of the genes associated with hereditary breast cancer.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Matt Ridley talks about chromosome 13, BRCA2 gene for breast cancer susceptibility.
Mark Skolnick talks about the hunt for BRCA1.
Mark Skolnick talks about moving on after the discovery of BRCA1 to find and clone another gene associated with breast cancer, BRCA2.
Mark Skolnick is Chief Scientific Officer at Myriad Genetics, Inc.