Chromosome 13: BRCA2 gene for breast cancer susceptibility, Matt Ridley
Interviewee: Matt Ridley. BRCA2, on chromosome 13, is one of the genes associated with hereditary breast cancer. Although gender, age and environmental effects are major risk factors for breast cancer, having a mutation in either the BRCA2 gene or BRCA1 gene (on chromosome 17) increases the risk. (DNAi Location: Genome > Tour > Genome spots > Chromosome 13: breast cancer > A Chromosome 13 story)
On chromosome 13, there's a gene called BRCA2. Mutations in this gene can increase someone's susceptibility to breast cancer. But most cancer isn't genetic in that sense â€“ it's not inherited. Most cancer is caused by events in our lives, in the environment. And yet in another sense, cancer is a purely genetic disease; it's a disease caused by genes doing things they shouldn't: normal genes, but genes that shouldn't be switched on to cause the growth, division, and proliferation of cells in the body. There's a whole series of genetic fail-safes to make sure this doesn't happen in a healthy body, but sometimes a whole series of mutations can knock out the fail-safes and the result is a cancer tumor.
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15939. What is breast cancer?
BRCA2, on chromosome 13, is one of the genes associated with hereditary breast cancer
15938. What is breast cancer?
BRCA1, on chromosome 17, is one of the genes associated with hereditary breast cancer.
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