Onto BRCA2, Mark Skolnick
Interviewee: Mark Skolnick. Mark Skolnick talks about moving on after the discovery of BRCA1 to find and clone another gene associated with breast cancer, BRCA2. (DNAi Location: Applications > Genes and medicine > Gene hunting > The finish line > Onto BRCA2)
Well just after we found BRCA1 we were then able to separate the whole set of families we had into those that were linked to BRCA1 and those that showed no linkage. So one member of our team, David Goldgar, teamed up with another player who hadn't been much of a player in the BRCA1 race, Mike Stratten, in an attempt to actually look at linkage information for those unlinked families, for the families that were not likely to be BRCA1 gene-carriers, and to look for the next gene, BRCA2. And why did we do it? We did it because it was the next logical step, your families are now purified, in that you have a clean set of just BRCA2 families. If we're going to offer diagnostic we want to offer a complete diagnostic, that is for both genes, not just one gene, so it was the logical next step for us.
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Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
Mark Skolnick is Chief Scientific Officer at Myriad Genetics, Inc.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Mary-Claire King talks about testing for breast cancer.
Mark Skolnick discusses how luck was a major element that helped his team win the race to find and clone BRCA1.
BRCA2, on chromosome 13, is one of the genes associated with hereditary breast cancer
BRCA1, on chromosome 17, is one of the genes associated with hereditary breast cancer.
Mark Skolnick recounts the complicated process of verifying that the gene they had found was indeed BRCA1.
Matt Ridley talks about chromosome 13, BRCA2 gene for breast cancer susceptibility.