Importance of genetic maps, Mary-Claire King
Interviewee: Mary-Claire King. Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available. (DNAi Location: Applications > Genes and medicine > Gene hunting > Markers > Moving slowly)
What made that sort of search possible in families like this, and there were 22 of them in our original study, was the development of a genetic map. When we first started the work, we and lots of other groups like us were developing the map as we went along. By the time that BRCA1 was ultimately identified in 1994, the map was essentially in place, thousands of markers had been placed on the map, what had taken me 17 years to do, between the, from the early Seventies until 1990 could be done now in weeks. It was the existence of the map was a phenomenal tool. So what we need to solve these problems are: families like this who will talk to us, keep talking to us over the years, and let us work with their DNA; maps, genetic maps; and then the capacity to know what sequence lies between markers in the genome.
mary claire king,dna maps,genetic maps,location applications,breast cancer,place thousands,dnai,interviewee,seventies,17 years,genome,genes,hunting,existence,medicine,map
- ID: 15128
- Source: DNALC.DNAi
- Download: Theora Video MPEG 4 Video
Related Content
15121. Little known in the 1970s about the causes of cancer, Mary-Claire King
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
15125. The early stages of the hunt for BRCA1, Mary-Claire King
Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not.
15118. What to look for in the hunt for BRCA1, Mary-Claire King
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
15243. The hunt for BRCA1, Mark Skolnick
Mark Skolnick talks about the hunt for BRCA1.
15123. Testing for mutations in BRCA1, Mary-Claire King
Mary-Claire King talks about testing for breast cancer.
15126. Using pedigress in the hunt for BRCA1, Mary-Claire King
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
15124. Better treatment for breast cancer, Mary-Claire King
Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
15127. Tedious process of early gene hunting, Mary-Claire King
Mary-Claire King talks bout tedious process of early gene hunting.
16055. Mary-Claire King
MARY-CLAIRE KING (1946- )