Importance of genetic maps, Mary-Claire King
Interviewee: Mary-Claire King. Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available. (DNAi Location: Applications > Genes and medicine > Gene hunting > Markers > Moving slowly)
What made that sort of search possible in families like this, and there were 22 of them in our original study, was the development of a genetic map. When we first started the work, we and lots of other groups like us were developing the map as we went along. By the time that BRCA1 was ultimately identified in 1994, the map was essentially in place, thousands of markers had been placed on the map, what had taken me 17 years to do, between the, from the early Seventies until 1990 could be done now in weeks. It was the existence of the map was a phenomenal tool. So what we need to solve these problems are: families like this who will talk to us, keep talking to us over the years, and let us work with their DNA; maps, genetic maps; and then the capacity to know what sequence lies between markers in the genome.
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Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Mary-Claire King talks about the search for a bit of DNA that would shed light on why some members of a family developed cancer while others did not.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Mark Skolnick talks about the hunt for BRCA1.
Mary-Claire King talks about testing for breast cancer.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
Mary-Claire King talks bout tedious process of early gene hunting.
MARY-CLAIRE KING (1946- )