Genetic and physical mapping
Interviewee: David Botstein<br><br> DNAi Location:<br>Genome>The Project>players>public<br><br> Genetic and physical mapping David Botstein, a prominent Stanford geneticist, talks about his initial involvement in Human Genome Project discussions and the value of genome maps.
I was invited largely because I had been involved in gene mapping, because a few years before in 1980 three colleagues and I had published a proposal for making a genetic map of the human genome with DNA markers that could be useful for finding disease genes. And by the time of the Santa Cruz meeting it was clear not only that you could find disease genes this way, but that it would really be useful to have more infrastructure, mainly a genetic and physical map that would greatly speed up this process.
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- ID: 16102
- Source: DNALC.DNAi
Nobel Laureate James Watson, the first director of the Human Genome Project, talks about his first reaction to the idea.
The critical first step to mapping the genome involved finding genetic markers. These markers are unique sequences that provide orientation points in the genome landscape.
Eric Lander talks about analysis in public and private Human Genome Projects.
Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.
Contains an image depicting the genome maps of HIV-1 HXB2, HIV-2 BEN, and SIV Sykes.
James Watson describes sequencing the human genome using markers and BACs, and Craig Venter explains using cDNA libraries, ESTs, and shotgun sequencing.
Model organisms such as yeast, bacteria, the mouse and the fruit fly are used by researchers to study biological systems. The genomes of these organisms have been mapped and sequenced.
Craig Venter, leader of the private effort at Celera Genomics, speaks about his company's reliance on the public data for reassembly of the Celera sequence.
Ewan Birney, one of the leading analysts involved in the Human Genome Project, takes you on an informal tour of a chromosome.
15477. The public Human Genome Project: mapping the genome, sequencing, and reassembly. 3D animation.
The public Human Genome Project: mapping the genome, sequencing, and reassembly.