Genetic and physical mapping

Interviewee: David Botstein<br><br> DNAi Location:<br>Genome>The Project>players>public<br><br> Genetic and physical mapping David Botstein, a prominent Stanford geneticist, talks about his initial involvement in Human Genome Project discussions and the value of genome maps.

I was invited largely because I had been involved in gene mapping, because a few years before in 1980 three colleagues and I had published a proposal for making a genetic map of the human genome with DNA markers that could be useful for finding disease genes. And by the time of the Santa Cruz meeting it was clear not only that you could find disease genes this way, but that it would really be useful to have more infrastructure, mainly a genetic and physical map that would greatly speed up this process.

genome maps,human genome project,disease genes,maps california,dna markers,physical mapping,initial involvement,genetic mapping,project discussions,gene mapping,interviewee,david botstein,geneticist,map of the human genome,santa cruz,stanford,colleagues,proposal,infrastructure,physical map

  • ID: 16102
  • Source: DNALC.DNAi

Related Content

15425. First reactions to the Human Genome Project, James Watson

Nobel Laureate James Watson, the first director of the Human Genome Project, talks about his first reaction to the idea.

  • ID: 16102
  • Type: video
  • Source: DNAi

15908. Maps and markers

The critical first step to mapping the genome involved finding genetic markers. These markers are unique sequences that provide orientation points in the genome landscape.

  • ID: 16102
  • Type: video
  • Source: DNAi

15326. Analysis in public and private Human Genome Projects, Eric Lander

Eric Lander talks about analysis in public and private Human Genome Projects.

  • ID: 16102
  • Type: video
  • Source: DNAi

15128. Importance of genetic maps, Mary-Claire King

Mary-Claire King talks about the tedious process of hunting for genes in the days before genetic maps (based on thousands of markers) were readily available.

  • ID: 16102
  • Type: video
  • Source: DNAi

16085. HIV/SIV Genome Maps

Contains an image depicting the genome maps of HIV-1 HXB2, HIV-2 BEN, and SIV Sykes.

  • ID: 16102
  • Type: video
  • Source: DNAi

16812. Animation 39: A genome is an entire set of genes.

James Watson describes sequencing the human genome using markers and BACs, and Craig Venter explains using cDNA libraries, ESTs, and shotgun sequencing.

  • ID: 16102
  • Type: video
  • Source: DNALC.DNAFTB

15566. Model organisms (yeast, bacteria, mouse, fruit fly)

Model organisms such as yeast, bacteria, the mouse and the fruit fly are used by researchers to study biological systems. The genomes of these organisms have been mapped and sequenced.

  • ID: 16102
  • Type: video
  • Source: DNAi

15367. Using data from the public project, Craig Venter

Craig Venter, leader of the private effort at Celera Genomics, speaks about his company's reliance on the public data for reassembly of the Celera sequence.

  • ID: 16102
  • Type: video
  • Source: DNAi

15293. How the information in the human genome is stored and expressed, Ewan Birney

Ewan Birney, one of the leading analysts involved in the Human Genome Project, takes you on an informal tour of a chromosome.

  • ID: 16102
  • Type: video
  • Source: DNAi

15477. The public Human Genome Project: mapping the genome, sequencing, and reassembly. 3D animation.

The public Human Genome Project: mapping the genome, sequencing, and reassembly.

  • ID: 16102
  • Type: video
  • Source: DNALC.DNAi