Was she at increased risk?, Denise
Interviewee: Denise. Denise talks about learning about DNA, and deciding if she wanted to know if she was at increased risk for breast cancer. (DNAi Location: Applications > Genes and medicine > Gene testing > Denise > Was she at increased risk?)
I went into the room and we sat down and Dr. Weber started explaining, you know, DNA, how DNA works, and she did an absolutely fabulous job of explaining DNA to somebody that had never heard anything about DNA, to me. And it, it made it, it made it seem clear to me and something I could understand. And she told me that they had information for me that would tell me if I had this marker, and I remember her taking a pause and asking me, do you want your information. And I said yes I do want my information, but thinking in the back of my mind I really did not want this information. But I knew that I needed to just face it, you know, head-on.
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Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
Barbara Weber talks about how she had discovered information that could be useful to families afflicted with hereditary breast cancer even before the gene was found.
Denise talks about her family's affliction with inherited breast cancer and her decision to have her breasts removed as a preventive measure.
Barbara Weber discusses how information from the pedigrees she used in her studies could show which family members were at increased risk for cancer.
Denise talks about the emotional moment when she found out she had been spared the "family curse."
Barbara Weber talks about the dramatic moment when she realized she had information that could change the life of her patient's sister.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Genetic testing changed Denise's life.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
BRCA1, on chromosome 17, is one of the genes associated with hereditary breast cancer.