Information from the pedigree, Barbara Weber
Interviewee: Barbara Weber. Barbara Weber discusses how information from the pedigrees she used in her studies could show which family members were at increased risk for cancer. (DNAi Location: Applications > Genes and Medicine > Gene testing > Barbara Weber > Information from the pedigree)
The more she [Vicky, her patient] talked about her family and what the structure of her family was, she was describing her sister who had died and her brother who was a certain age and so on. The picture in my mind of the family tree came to me and made me suspicious that this was a family that wasn't just part of a pretty big study of families but this was a specific family that we had been working on very hard to use for mapping BRCA1 before the gene was actually identified. And so what started to occur to me was that no one I don't think had really thought about this very much, I certainly hadn't and I don't think Francis [Collins, her colleague] had either. That the information that we had on this pedigree now enabled us to tell families - specifically this family and people - specifically these two women what we knew which was why there was too much breast cancer in this family and who was at risk and who wasn't.
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Barbara Weber talks about how she had discovered information that could be useful to families afflicted with hereditary breast cancer even before the gene was found.
Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Barbara Weber talks about the dramatic moment when she realized she had information that could change the life of her patient's sister.
Pedigrees are valuable tools in the study of disease inheritance.
Barbara Weber talks about delivering the news.
Mary-Claire King talks about testing for breast cancer.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.
Mark Skolnick is Chief Scientific Officer at Myriad Genetics, Inc.
Mark Skolnick talks about moving on after the discovery of BRCA1 to find and clone another gene associated with breast cancer, BRCA2.