Purpose of finding the gene, Barbara Weber
Interviewee: Barbara Weber. Barbara Weber talks about how she had discovered information that could be useful to families afflicted with hereditary breast cancer even before the gene was found. (DNAi Location: Applications > Genes and Medicine > Gene testing > Barbara Weber > Purpose of finding the gene)
And it was really as I started to talk to her [Vicky, her patient] about what the study was for - the purpose of finding these genes and why the families were important in the studies - that she started to give back to me why she wanted the information that suddenly it sort of came together that, oh my God we actually do have the information even though the gene hadn't been identified yet. I think that was part of it, we were so focused on the idea of finding the gene and what we would do when we had the gene that we didn't, I mean it's an obvious genetic thing it wasn't any big discovery it's just that we had been focused on finding the gene not the idea that we already had information with the markers that we could use if patients or families had a reason to need to know that information.
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Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
Barbara Weber discusses how information from the pedigrees she used in her studies could show which family members were at increased risk for cancer.
Barbara Weber talks about delivering the news.
Barbara Weber talks about the dramatic moment when she realized she had information that could change the life of her patient's sister.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Genetic testing changed Denise's life.
Denise talks about learning about DNA, and deciding if she wanted to know if she was at increased risk for breast cancer.
Denise talks about the emotional moment when she found out she had been spared the "family curse."
Denise talks about her family's affliction with inherited breast cancer and her decision to have her breasts removed as a preventive measure.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.