Seeing who has the marker, Barbara Weber
Interviewee: Barbara Weber. Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not. (DNAi Location: Applications > Genes and Medicine > Gene testing > Barbara Weber > Seeing who has the marker)
The numbers underneath them are the genetic markers that we were using and this was actually the pedigree that came into my mind as I was talking to Vicky that day in clinic. This is Vicky here, this is her sister who had died before I met them and this is her sister Denise and what you can see just sort of generally looking is that what we had been doing was circling the markers that went with the disease in this family and they're all the same, you probably can't see them but this, this, this, this, this - all these people who have breast cancer have the same series of markers that are outlined here. And what I could see clearly in my head was that Denise - that's her - didn't have them.
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Barbara Weber talks about how she had discovered information that could be useful to families afflicted with hereditary breast cancer even before the gene was found.
Barbara Weber discusses how information from the pedigrees she used in her studies could show which family members were at increased risk for cancer.
Barbara Weber talks about delivering the news.
Barbara Weber talks about the dramatic moment when she realized she had information that could change the life of her patient's sister.
Denise talks about learning about DNA, and deciding if she wanted to know if she was at increased risk for breast cancer.
Denise talks about the emotional moment when she found out she had been spared the "family curse."
Genetic testing changed Denise's life.
Denise talks about her family's affliction with inherited breast cancer and her decision to have her breasts removed as a preventive measure.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mary-Claire King talks about her first steps toward finding the gene responsible for certain kinds of inherited breast cancer.