Since the mid-1800s, pedigrees have been used to track human heredity. Barbara Weber and her colleagues used pedigrees of families with a high incidence of breast cancer to aid their gene-mapping work, and found that the pedigrees could contain useful information for the families they studied.
human heredity,incidence of breast cancer,barbara weber,mapping work,breast cancer,pedigrees,gene mapping,mid 1800s,valuable tools,pedigree,inheritance,colleagues
- ID: 15705
- Source: DNALC.DNAi
Barbara Weber discusses how information from the pedigrees she used in her studies could show which family members were at increased risk for cancer.
Barbara Weber shows how information from her study on genetic markers associated with inherited breast cancer indicated which family members were at increased risk and which were not.
Barbara Weber talks about how she had discovered information that could be useful to families afflicted with hereditary breast cancer even before the gene was found.
Barbara Weber talks about delivering the news.
Genetic testing changed Denise's life.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Barbara Weber talks about the dramatic moment when she realized she had information that could change the life of her patient's sister.
Mark Skolnick is Chief Scientific Officer at Myriad Genetics, Inc.
This section reviews how epidemiologists look for cancer “hot spots” – regions with high cancer rates.
Denise talks about her family's affliction with inherited breast cancer and her decision to have her breasts removed as a preventive measure.