Advantages of mouse models, Mario Capecchi
Interviewee: Mario Capecchi. Mouse researcher Mario Capecchi talks about the similarities in mammalian anatomy and physiology. (DNAi Location: Manipulation > Techniques > Model organisms > Interviews > What's nice about the mouse?)
A nice thing about the mouse is that, I mean if you look at the hand, in this hand we have about thirty bones, and if you look at the human hand and the mouse hand, it's the exact same set of thirty bones, they're just slightly different shapes so that the hand of the mouse will look a little different and it'll be a lot smaller. But in terms of the detail, each little bone for example, in this particular finger we have three bones, one here, one here, one here, what are called phalangeal bones, and the mouse will have the exact same phalangeal bones. So whatever we perturb, when we inactivate a gene for example and this little finger disappears, we know now we're in the program for making a little finger, but not only in the mouse but that same program will also be responsible for making the little finger in the human.
mario capecchi,mammalian anatomy,anatomy and physiology,three bones,manipulation techniques,model organisms,limb formation,mouse models,different shapes,mouse hand,dnai,little finger,mouse mouse,interviewee,nice thing,mice,researcher
Mario Capecchi discusses the similarities between mouse and human limb formation, and how his work might lead to limb regeneration in the future.
Mice are small, easy to keep, and complete a generation in only ten weeks. They are also rather closely related to human beings.
Mario Capecchi continues his explanation of the technique he uses to control genes in mice.
Mario Capecchi talks about manipulating embryonic stem (ES) cells to make specific mutations in mouse embryos.
Mario Capecchi talks about the advantages of working with mice to study genetic disorders.
Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.
Mario Capecchi describes proteomics; the large-scale study of protein structure and function. Brian Sauer explains gene knock outs.
image of a mouse.
Mario Capecchi explains the technique he uses to control genes in mice.
Mario Capecchi discusses homologous recombination, the technique he developed to introduce a desired mutation into the DNA of living cells.