Mouse (Mus musculus)
Mice are small, easy to keep, and complete a generation in only ten weeks. They are also rather closely related to human beings.
As a mammal, a mouse is rather closely related to a human being. However, it is small, easy to keep, and completes a generation in only ten weeks. It shares more genes, anatomy, and physiology with us than the simpler model systems – bacteria, worms, or flies. Many laboratory strains of mice have been inbred to be genetically identical, which makes it easier to see the effects of an experimental treatment or change in a single gene. A method called homologous recombination allows scientists to precisely replace virtually any mouse gene with a mutated copy of the same gene or a related gene from another organism. A “transgenic” mouse is usually created by injecting a foreign gene into embryonic stem cells and then implanting the manipulated embryos into a surrogate mother. Transgenic mice carrying human disease genes are models for Huntington’s disease, sickle cell anemia, Alzheimer’s disease, and many cancers.
mouse, mus musculus, mice, model, system, organism, transgenic, recombination
- ID: 1712
- Source: DNALC.G2C
Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.
Model organisms such as yeast, bacteria, the mouse and the fruit fly are used by researchers to study biological systems. The genomes of these organisms have been mapped and sequenced.
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Mario Capecchi describes proteomics; the large-scale study of protein structure and function. Brian Sauer explains gene knock outs.
Professor Seth Grant outlines one way in which the Genes to Cognition Research Programme uses model organisms to study learning and memory in humans.
image of a mouse.
Professor David Lewis outlines how model organisms such as mice can help uncover the interplay of the genetic components in schizophrenia.
Mouse researcher Mario Capecchi talks about the similarities in mammalian anatomy and physiology.
This method uses homologous recombination to disable a gene of interest to produce a genetic knockout.
Doctor Brian Bacskai discusses how his group uses optical image to record plaque formation in Alzheimer's-type mice.