Bipolar Disorder Candidate Genes

While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.

We know from family and twin studies that bipolar is a highly genetic disorder. A study of 11,288 same-sex twin pairs in Denmark by Bertelsen and colleagues (1977) found that approximately 58% of monozygotic (identical) twins were concordant for bipolar disorder, as compared with 17% of dizygotic (fraternal) twins. While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal. One explanation for the difficulty in finding genes for bipolar is that it is a highly complex disorder. Genes with the strongest association are also candidate genes for schizophrenia (in particular), as well as major depression. This is not surprising given that the disorders share some common symptoms. For example, psychosis is a feature of both bipolar and schizophrenia (although the delusions and hallucination in schizophrenia seem to be related to self-awareness as opposed to mood-incongruence). Candidate genes for bipolar disorder include G72/DAOA, DISC1, NRG1, TPH2, BDNF, 5-HTT, and DAT1.

bipolar, candidate, gene, G72, DAOA, DISC1, NRG1, TPH2, BDNF, 5-HTT, DAT1, slc6a4, slc6a3,

  • ID: 1484
  • Source: DNALC.G2C

Related Content

471. Chromosome Map of Disorders and Processes

An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.

  • ID: 1484
  • Type:
  • Source: G2C

2223. Bipolar disorder

An overview of bipolar disorder-related content on Genes to Cognition Online.

  • ID: 1484
  • Type:
  • Source: G2C

1483. DAT1 Gene

The dopamine transporter gene (DAT1/SLC6A3) is a membrane-spanning protein that mediates the reuptake of dopamine from the synapse. It has been associated with bipolar disorder and ADHD.

  • ID: 1484
  • Type:
  • Source: G2C

923. DAOA/G72

Polymorphisms of DAOA are associated with schizophrenia and bipolar disorder risk.

  • ID: 1484
  • Type:
  • Source: G2C

918. 5-HTT Gene

The 5-HTT gene has been associated with both depression and autism.

  • ID: 1484
  • Type:
  • Source: G2C

1464. Candidate Genes for Depression

The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.

  • ID: 1484
  • Type:
  • Source: G2C

868. Candidate Genes for Schizophrenia

An interactive chromosome map of the genes and loci associated with schizophrenia.

  • ID: 1484
  • Type:
  • Source: G2C

1466. TPH2 Gene

Because serotonin is critical to so many processes in the central nervous system, genes involved in its synthesis are interesting to neuroscientists.

  • ID: 1484
  • Type:
  • Source: G2C

921. NRG1 Gene

Increased neuregulin signaling in schizophrenia may suppress the NMDA receptor, leading to lowered glutamate levels.

  • ID: 1484
  • Type:
  • Source: G2C

504. DISC1 Gene

Disrupted in Schizophrenia 1 (DISC1) is a candidate gene for schizophrenia.

  • ID: 1484
  • Type:
  • Source: G2C