Increased neuregulin signaling in schizophrenia may suppress the NMDA receptor, leading to lowered glutamate levels.
Neuregulin 1 (NRG1) is a growth factor that stimulates neuron development and differentiation. Originally identified as the proto-oncogene (tumor activator) Neu/ErbB2, NRG1 contains immunoglobulin and epidermal growth factor-like domains. NRG1 interacts with cells through the Neu/ErbB2 receptor, which is a member of the epidermal growth factor receptor family. Increased neuregulin signaling in schizophrenia may suppress the NMDA receptor, leading to lowered glutamate levels. NRG1 also regulates the postsynaptic density (PSD-95). Differential RNA splicing gives rise to a variety of isoforms that function as growth factors in different cell types. The beginning (5â€™ region) of the gene has been most implicated in schizophrenia; however no mutations have yet been identified in coding regions of the gene that are related to schizophrenia. In addition, a number of recent studies have identified NRG1 as a candidate gene for bipolar disorder.
gene, schizophrenia, schizophrenic, neuregulin 1, neuregulin1, nrg1, nrg 1, Neu/ErbB2, erbb2, neu, psd95, psd-95, epidermal, growth, factor, receptor
- ID: 921
- Source: DNALC.G2C
An interactive chromosome map of the genes and loci associated with schizophrenia.
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
An interactive chromosome map of the genes and loci associated with learning and memory.
Professor Seth Grant explains that taking cocaine reduces the expression of the PSD95 protein, which can lead to memory impairments.
An overview of bipolar disorder-related content on Genes to Cognition Online.
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
Professor David Porteous discusses genes for schizophrenia and points out that susceptibility likely aligns to a combination of genetic variants.