Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse Psd95 proteins. Migaud and colleagues (1998) examined mice that lack this protein and found evidence of severe impairments in spatial learning. This was reflected by irregularities in long-term potentiation in the brain. These changes may be caused by a disruption of the NMDA receptor, which can bind PSD-95, at the synapse. In the absence of PSD-95, the NMDA receptor synaptic complex may become uncoupled from pathways that control plasticity and learning.
Discs, large homolog 4, DLG4, learning, memory, psd95, gene, protein, nmda, synapse, disruption, plasticity
- ID: 1368
- Source: DNALC.G2C
An interactive chromosome map of the genes and loci associated with learning and memory.
Discs, large homolog 3 (DLG3) is a gene associated with learning and memory. DLG3 encodes synapse-associated protein 102 (SAP102).
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.
An interactive chromosome map of the genes and loci associated with schizophrenia.
Disrupted in Schizophrenia 1 (DISC1) is a candidate gene for schizophrenia.
Students will experiment with an interactive animation to compare mutant and wild-type mice in a water maze. They will analyze data and discuss findings of a research paper.
This method uses homologous recombination to disable a gene of interest to produce a genetic knockout.
Professor Seth Grant introduced the word 'hebbosome' to describe the multiprotein complex that converts neural activity patterns into a memory trace.
Professor David Porteous explains that DISC1 is expressed prominently in the hippocampus. More specifically, it is expressed in the mitochondria of hippocampal cells.