Discs, large homolog 3 (DLG3) is a gene associated with learning and memory. DLG3 encodes synapse-associated protein 102 (SAP102).
Discs, large homolog 3 (DLG3) is a gene associated with learning and memory. DLG3 encodes synapse-associated protein 102 (SAP102). During early brain development, SAP102 is expressed in neurons in the postsynaptic density of excitatory synapses. It interacts directly with the NMDA receptor complex, which plays an important role in long-term potentiation and memory formation. Tarpey and colleagues (2004) linked mutations in DLG3 with X-linked mental retardation, which prematurely creates a stop codon, causing the protein to terminate too soon. It is likely that this mutation disrupts SAP102 interactions with the NMDA receptor complex. Cuthbert and colleagues (2007) found that mice lacking SAP102 had impaired synaptic plasticity and showed deficits in spatial learning.
dlg3, sap102, discs, large, homolog 3, synapse-associated protein 102, long term potentiation, postsynaptic density, learning and memory, nmda receptor, plasticity, mental retardation, x-linked, linkage
- ID: 1367
- Source: DNALC.G2C
1390. Genes for Learning and Memory
An interactive chromosome map of the genes and loci associated with learning and memory.
898. SAP102 Swimming Mice
Compare SAP102 knockout mice and wild-type mice on a task designed to measure spatial learning and memory.
1403. SAP102 - Sanger Institute Research
Genes to Cognition researchers discover a genetic basis for higher mental functions that provides new insights into autism and learning disability.
1363. Genes for memory (lesson)
Students will experiment with an interactive animation to compare mutant and wild-type mice in a water maze. They will analyze data and discuss findings of a research paper.
1368. DLG4 Gene
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
1997. Learning and memory
Learning and memory are two intimately linked cognitive processes that stem from interactions with the environment (experience).
550. The Neural Code
Cognitive information is encoded in patterns of nervous activity and decoded by molecular listening devices at the synapse. Professor Seth Grant explains how different patterns of neural firing are critical to cognition.
865. Mental Retardation
Mental retardation: struggle, stigma, science.
1277. Molecules for Memory
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.
1213. PSD-95 and Learning
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.