PSD-95 Mutations

In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.

PSD95 is a protein that binds to the inside surface of neurotransmitter receptors, and when we mutated that protein in mice, we found that the animals had impaired learning, but the receptor still acted normally. This established that neurotransmitter receptors act through the proteins associated with them to lay down the memory trace. It’s not just about the receptor, it’s about the proteins associated with it.

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1213. PSD-95 and Learning

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  • Source: G2C

1220. Cocaine and Memory Loss

Professor Seth Grant explains that taking cocaine reduces the expression of the PSD95 protein, which can lead to memory impairments.

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Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.

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1216. Hebbosome

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897. Gene knockout in mice

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868. Candidate Genes for Schizophrenia

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1363. Genes for memory (lesson)

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1997. Learning and memory

Learning and memory are two intimately linked cognitive processes that stem from interactions with the environment (experience).

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