Professor Seth Grant introduced the word 'hebbosome' to describe the multiprotein complex that converts neural activity patterns into a memory trace.
A hebbosome is a conjunction of two words: â€˜someâ€™, meaning body, and â€˜hebb,â€™ referring to the name of Donald Hebb, a very influential psychologist in the field of learning and memory who in 1949 in his book, 'The Organization of Behavior,' predicted the existence of some metabolic machinery that would convert patterns of neural activity into a memory trace. And the proteins that are found associated with PSD95 and the NMDA receptor, which are a body or a â€˜someâ€™ of proteins, do exactly what Hebb predicted. And as a tribute to his prediction, we have used that term.
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Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.
Cognitive information is encoded in patterns of nervous activity and decoded by molecular listening devices at the synapse. Professor Seth Grant explains how different patterns of neural firing are critical to cognition.
Professor Tom O'Dell describes the role played by NMDA receptors, as part of a large multi-protein complex, in facilitating long-term potentiation (LTP).
In studies of PSD95, Professor Seth Grant's group showed that memories are formed when neurotransmitter receptors associate with proteins.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
Professor Seth Grant explains that taking cocaine reduces the expression of the PSD95 protein, which can lead to memory impairments.
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.
An interactive chromosome map of the genes and loci associated with learning and memory.
Professor Seth Grant highlights PSD95 as an important example of a protein associated with a neurotransmitter receptor that affects learning.
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.