NMDA Receptors, Multi-protein Complexes, & LTP
Professor Tom O'Dell describes the role played by NMDA receptors, as part of a large multi-protein complex, in facilitating long-term potentiation (LTP).
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1107. Depotentiation
Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
1108. Synaptic Plasticity (1)
Professor Tom O'Dell discusses synaptic plasticity - the strengthening and weakening of synaptic connections between neurons.
1106. Phosphorylation and Synaptic Plasticity
Professor Tom O'Dell comments that phosphorylation plays a crucial role in synaptic plasticity.
811. The Glutamate System
Professor Trevor Robbins describes some of the key functions of the excitatory glutamate system, which is integral to information processing and long-term potentiation.
1105. Phosphorylation
Professor Tom O'Dell defines phosphorylation - the addition of a phosphate group to a protein molecule to regulate gene function.
1211. What is NMDA?
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
1101. AMPA and NMDA Receptors
Professor Graham Collingridge describes the roles played by NMDA and AMPA receptors in long-term potentiation (LTP).
2141. Glutamate uptake decreased in Alzheimer's disease
Professor Dennis Selkoe discusses the finding that amyloid beta seems to decrease the uptake of glutamate by synapses.
550. The Neural Code
Cognitive information is encoded in patterns of nervous activity and decoded by molecular listening devices at the synapse. Professor Seth Grant explains how different patterns of neural firing are critical to cognition.
1104. Electrophysiology - Techniques (1)
Professor Tom O'Dell describes different techniques for studying the physiology of the nervous system.