AMPA and NMDA Receptors
Professor Graham Collingridge describes the roles played by NMDA and AMPA receptors in long-term potentiation (LTP).
So the way we believe LTP works is that there is a brief activation of the NMDA receptor, and then this leads to alterations in how the AMPA receptor works. So, in LTP, the AMPA receptor becomes more efficient and this leads to an increase in the synaptic communication. It is believed that this can occur because at the synapse, there is an increase in the number of AMPA receptors which are present, and under certain different circumstances the properties of the AMPA receptor may be changed so that they work more efficiently.
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Professor Graham Collingridge describes the glutamate receptor, AMPA, the workhorse receptor for communicating information.
Professor Graham Collingridge briefly describes how the NMDA receptor facilitates Hebbian learning (a mechanism of synaptic plasticity).
Professor Graham Collingridge describes the process of long-term potentiation (LTP) - the process by which synapses increase their efficiency.
Professor Graham Collingridge describes the process of long-term depression (LTD), a way of decreasing the efficiency of synaptic transmission.
Professor Dennis Selkoe discusses the finding that amyloid beta seems to decrease the uptake of glutamate by synapses.
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.
Professor Graham Collingridge explains that synaptic plasticity is the way most information is stored in the central nervous system.
Learning and memory are two intimately linked cognitive processes that stem from interactions with the environment (experience).
Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
Professor Trevor Robbins describes some of the key functions of the excitatory glutamate system, which is integral to information processing and long-term potentiation.