Professor Graham Collingridge describes the glutamate receptor, AMPA, the workhorse receptor for communicating information.
There are two major types of glutamate receptor at most synapses which show LTP, one of which is the AMPA receptor, and the other is called the NMDA receptor. The AMPA receptor is responsible for mediating the synaptic response during low frequency transmission in the brain. It is, if you like, the workhorse receptor for communicating information in the brain.
glutamate, receptor, ampa, nmda, synapse, graham, collingridge
Professor Graham Collingridge describes the roles played by NMDA and AMPA receptors in long-term potentiation (LTP).
Professor Graham Collingridge briefly describes how the NMDA receptor facilitates Hebbian learning (a mechanism of synaptic plasticity).
Professor Dennis Selkoe discusses the finding that amyloid beta seems to decrease the uptake of glutamate by synapses.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
Professor Graham Collingridge describes the process of long-term potentiation (LTP) - the process by which synapses increase their efficiency.
Professor Trevor Robbins describes some of the key functions of the excitatory glutamate system, which is integral to information processing and long-term potentiation.
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.
Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.
Professor Graham Collingridge describes the process of long-term depression (LTD), a way of decreasing the efficiency of synaptic transmission.
Professor Graham Collingridge explains that synaptic plasticity is the way most information is stored in the central nervous system.