NMDA Receptor and Learning (2)
Professor Graham Collingridge briefly describes how the NMDA receptor facilitates Hebbian learning (a mechanism of synaptic plasticity).
The NMDA receptor has very interesting properties, unique properties, which enable it to confer upon a synapse the so called property of Hebbian function. It gives a mechanistic explanation for the Hebbian synapse, which is one of the most important concepts of neuropsychology.
NMDA, receptor, hebbian. learning, synapse, graham, collingridge
Professor Graham Collingridge describes the glutamate receptor, AMPA, the workhorse receptor for communicating information.
Professor Graham Collingridge describes the roles played by NMDA and AMPA receptors in long-term potentiation (LTP).
Professor Graham Collingridge describes the process of long-term potentiation (LTP) - the process by which synapses increase their efficiency.
Professor Graham Collingridge describes the process of long-term depression (LTD), a way of decreasing the efficiency of synaptic transmission.
Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.
Professor Graham Collingridge explains that synaptic plasticity is the way most information is stored in the central nervous system.
Professor Dennis Selkoe discusses the finding that amyloid beta seems to decrease the uptake of glutamate by synapses.
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
Discs, large homolog 3 (DLG3) is a gene associated with learning and memory. DLG3 encodes synapse-associated protein 102 (SAP102).