Synaptic Plasticity (1)
Professor Tom O'Dell discusses synaptic plasticity - the strengthening and weakening of synaptic connections between neurons.
So the neural code, or the patterns of synaptic activity on both the pre- and postsynaptic side of the synapse, are sort of the crucial determinants of synaptic plasticity. In general, in many, many excitatory synapses in the brain â€“ probably most if not all excitatory synapses in the brain â€“ when a presynaptic partner of the synapse, when that cell is active at about the same time the postsynaptic cell is, that fulfills the requirement for the induction of long-tern potentiation, or LTP. Cells that are firing together at that same time â€“ that pattern of activity, these two happening conjointly â€“ that is the trigger, the condition, for causing long term potentiation. When cells are firing out of sequence, or out of synch, that in turn can cause the opposite change in synaptic strength. It can trigger long term depression, or LTD.
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Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
Professor Tom O'Dell comments that phosphorylation plays a crucial role in synaptic plasticity.
Professor Tom O'Dell describes the role played by NMDA receptors, as part of a large multi-protein complex, in facilitating long-term potentiation (LTP).
Professor Graham Collingridge describes the process of long-term depression (LTD), a way of decreasing the efficiency of synaptic transmission.
Long-term Potentiation of synaptic transmission is commonly referred to as LTP. It can be recorded in many parts of the nervous system, but is very widely studied in the hippocampus.
Professor Dennis Selkoe notes amyloid beta oligomers are very potent inhibitors of long-term potentiation (LTP) and can 'short circuit' synapses in the hippocampus.
Professor Tom O'Dell defines phosphorylation - the addition of a phosphate group to a protein molecule to regulate gene function.
Professor Tom O'Dell describes different techniques for studying the physiology of the nervous system.
Professor Seth Grant explains that long-term potentiation is based on the principle that synapses become stronger with experience.
Professor Eric Kandel introduces the concept of long-term potentiation, which refers to change in the strength of synaptic connections.