Professor Seth Grant explains that long-term potentiation is based on the principle that synapses become stronger with experience.
Long-term potentiation and long-term depression of synaptic transmission is a highly studied area of neurobiology. It is studied because it is thought, although not proven, to be a memory mechanism. Simply put, if synapses become stronger with experience, then it seems logical that that might be a way of storing memories.
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Professor Seth Grant discusses the complicated relationship between long-term potentiation and learning/memory.
Professor Seth Grant explains that long-term memories are created when the synapse sends a signal to the nucleus to activate certain genes.
Professor Seth Grant explains that long-term potentiation may last for days or weeks, but is usually studied over the course of several hours.
Cognitive information is encoded in patterns of nervous activity and decoded by molecular listening devices at the synapse. Professor Seth Grant explains how different patterns of neural firing are critical to cognition.
Professor Kenneth Kosik discusses changes in synapses that accompany long-term potentiation, which include enlarged dendritic spines.
Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.
Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
Professor Tom O'Dell discusses synaptic plasticity - the strengthening and weakening of synaptic connections between neurons.
Professor Graham Collingridge describes the process of long-term potentiation (LTP) - the process by which synapses increase their efficiency.
Long-term Potentiation of synaptic transmission is commonly referred to as LTP. It can be recorded in many parts of the nervous system, but is very widely studied in the hippocampus.