Long-term Potentiation

Professor Seth Grant explains that long-term potentiation is based on the principle that synapses become stronger with experience.

Long-term potentiation and long-term depression of synaptic transmission is a highly studied area of neurobiology. It is studied because it is thought, although not proven, to be a memory mechanism. Simply put, if synapses become stronger with experience, then it seems logical that that might be a way of storing memories.

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Professor Seth Grant discusses the complicated relationship between long-term potentiation and learning/memory.

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  • Source: G2C

1217. Long- and Short-term Memory Differences (2)

Professor Seth Grant explains that long-term memories are created when the synapse sends a signal to the nucleus to activate certain genes.

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1209. How Long is LTP?

Professor Seth Grant explains that long-term potentiation may last for days or weeks, but is usually studied over the course of several hours.

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550. The Neural Code

Cognitive information is encoded in patterns of nervous activity and decoded by molecular listening devices at the synapse. Professor Seth Grant explains how different patterns of neural firing are critical to cognition.

  • ID: 550
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2037. Synapse changes during learning

Professor Kenneth Kosik discusses changes in synapses that accompany long-term potentiation, which include enlarged dendritic spines.

  • ID: 2037
  • Source: G2C

1212. NMDA Receptors and Learning (1)

Professor Seth Grant explains that NMDA receptors are important to forming memories - if we block NMDA receptors, we can block learning.

  • ID: 1212
  • Source: G2C

1107. Depotentiation

Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.

  • ID: 1107
  • Source: G2C

1108. Synaptic Plasticity (1)

Professor Tom O'Dell discusses synaptic plasticity - the strengthening and weakening of synaptic connections between neurons.

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1098. Long-term Potentiation

Professor Graham Collingridge describes the process of long-term potentiation (LTP) - the process by which synapses increase their efficiency.

  • ID: 1098
  • Source: G2C

549. Long-term Potentiation

Long-term Potentiation of synaptic transmission is commonly referred to as LTP. It can be recorded in many parts of the nervous system, but is very widely studied in the hippocampus.

  • ID: 549
  • Source: G2C