How Long is LTP?
Professor Seth Grant explains that long-term potentiation may last for days or weeks, but is usually studied over the course of several hours.
Long-term potentiation has been reported to last for as long as several weeks. But most of the time investigators study it for the course of an hour or two, in an in vitro situation where there is a brain slice in a culture dish. But in vivo recordings, in the intact animal, have shown it can last for days, and indeed weeks.
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1208. Long-term Potentiation
Professor Seth Grant explains that long-term potentiation is based on the principle that synapses become stronger with experience.
1111. Multiple Electrode Arrays
Professor Tom O'Dell explains how multiple electrode arrays are being used to study electrical activity in the brain.
1210. Long-term Potentiation and Learning
Professor Seth Grant discusses the complicated relationship between long-term potentiation and learning/memory.
928. Recording Electrical Activity in Brain Slices
Researchers from the Wellcome Trust Sanger Institute demonstrate how action potentials are recorded from brain slices, and how long-term potentiation is measured.
1104. Electrophysiology - Techniques (1)
Professor Tom O'Dell describes different techniques for studying the physiology of the nervous system.
1217. Long- and Short-term Memory Differences (2)
Professor Seth Grant explains that long-term memories are created when the synapse sends a signal to the nucleus to activate certain genes.
549. Long-term Potentiation
Long-term Potentiation of synaptic transmission is commonly referred to as LTP. It can be recorded in many parts of the nervous system, but is very widely studied in the hippocampus.
1403. SAP102 - Sanger Institute Research
Genes to Cognition researchers discover a genetic basis for higher mental functions that provides new insights into autism and learning disability.
1715. Human (Homo sapiens) Cell Cutures
When model organisms cannot provide the information needed to answer a particular research question, biologists can turn to cultured human cells.
1283. Long-term Potentiation
Professor Eric Kandel introduces the concept of long-term potentiation, which refers to change in the strength of synaptic connections.