Professor Eric Kandel introduces the concept of long-term potentiation, which refers to change in the strength of synaptic connections.
Long-term potentiation is a form of synaptic plasticity. Plasticity refers to change in the strength of synaptic connections. Long-term potentiation is a form of synaptic plasticity whereby activity in neurons gives rise to a change in synaptic strength. It can persist for many minutes, to hours, and even days in the mammalian brain.
mammalian brain, synaptic connections, plasticity, long term potentiation
Professor Tom O'Dell discusses synaptic plasticity - the strengthening and weakening of synaptic connections between neurons.
Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
Professor Jeff Lichtman examines the concept of synaptic plasticity, a term that refers to the way the brain changes.
Long-term Potentiation of synaptic transmission is commonly referred to as LTP. It can be recorded in many parts of the nervous system, but is very widely studied in the hippocampus.
Professor Eric Kandel discusses changes in synapse structure during long-term memory. Research indicates these changes are synapse-specific and not neuron-wide.
Reelin is a gene that is important to learning and memory. It is also a candidate gene for autism, schizophrenia, and Alzheimer's disease.
Discs, large homolog 4 (DLG4) is a gene associated with learning and memory. The human DLG4 protein is 99% identical to the rat and mouse PSD-95 proteins.
Discs, large homolog 3 (DLG3) is a gene associated with learning and memory. DLG3 encodes synapse-associated protein 102 (SAP102).
Professor James Eberwine discusses the structural changes in a cell related to long-term potentiation. These include changes in the shape of dendritic spines.
Professor Seth Grant explains that long-term potentiation is based on the principle that synapses become stronger with experience.