The 5-HTT gene has been associated with both depression and autism.
The serotonin transporter protein (5-HTT/SLC6A4) transports the neurotransmitter serotonin from synapses to presynaptic neurons. It seems to be an important component in the physiological response to cocaine and amphetamines. It is expressed in the central and peripheral nervous systems. The gene has long and short variants, which are identifiable by the insertion or deletion of 44 base pairs close to the beginning of the gene’s transcription site. A study by Caspi and colleagues (2003) found that individuals with the shorter variant were more likely to become depressed following environmental stress. Additionally, Kaufman and colleagues (2006) found a three-way interaction between the presence of the allele, a BDNF polymorphism, and stress. However, recent large-scale studies have failed to replicate these findings. Autistic individuals also show elevated platelet serotonin levels, and have been shown to respond to selective serotonin reuptake inhibitor (SSRI) medications.
5-htt, SLC6A4, serotonin, transporter, gene, unipolar, depression, autism. vntr, serotoninergic
- ID: 918
- Source: DNALC.G2C
Use this chromosome map to explore genes associated with autism.
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.
The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.
Serotonin is a neurotransmitter associated with a number of cognitive disorders, namely depression, bipolar and schizophrenia. Professor Trevor Robbins explains how the serotoninergic system works.
The serotonin transporter gene may affect neural circuits connecting the amygdala and the cingulate and cause depression.
Professor Wayne Drevets discusses the ways in which stress can lead to depression. Research into interactions between stress and genes include a mutation in the serotonin transporter region.
An overview of depression-related content on Genes to Cognition Online.
An overview of bipolar disorder-related content on Genes to Cognition Online.