Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.
Hydroxytryptamine receptor 2A (HTR2A/5-HTR2A/Setononin receptor 2A) is a serotonin receptor (5-hydroxytryptamine is a synonym for serotonin). It is also a G protein-coupled receptor, receiving molecules from outside and using them to activate signal transduction inside the cell. Serotonin is critical to many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause of depression. McMahon and colleagues (2006) investigated 68 candidate genes in 1953 patients with major depression. Only HTR2A was identified with response to antidepressives â€“ more specifically, a positive response to treatment was seen in patients with a specific single nucleotide polymorphism, rs7997012. Further evidence for an association between the serotonin receptor and depression was provided by Weisstaub and colleagues (2006), who found an association between Htr2a signaling in mice and performance on conflict anxiety paradigms.
depression, candidate, genes, hydroxytryptamine receptor 2A, HTR2A, 5-HTR2A, setononin, receptor 2A
- ID: 1467
- Source: DNALC.G2C
1464. Candidate Genes for Depression
The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.
847. Treating Depression
Individual variations in antidepressant treatment outcomes.
510. GRM3 Gene
Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.
916. GABRB3 Gene
GABA is the main inhibitory neurotransmitter in the adult brain. GABRA3 is a candidate gene for autism.
1020. Pathways, A bevy of interactions
In this section learn that receptors activate each other before binding an adaptor molecule and an exchange factor.
915. AVPR1A Gene
AVPR1A is a candidate gene for autism.
1019. Pathways, Beneath the membrane
In this section learn that the binding of growth factors outside the cell causes receptors ends to intertwine and activate each other, and once active, the modified receptor ends interact with messenger proteins.
908. Autism Candidate Genes
Use this chromosome map to explore genes associated with autism.
2223. Bipolar disorder
An overview of bipolar disorder-related content on Genes to Cognition Online.
1109. NMDA Receptors, Multi-protein Complexes, & LTP
Professor Tom O'Dell describes the role played by NMDA receptors, as part of a large multi-protein complex, in facilitating long-term potentiation (LTP).