GABA is the main inhibitory neurotransmitter in the adult brain. GABRA3 is a candidate gene for autism.
GABA-A receptor, Beta-3 Polypeptide (GABRB3) maps to chromosomal region 15q11.2-q12 in humans. GABA is the main inhibitory neurotransmitter in the adult brain. During neurotransmission GABA activates the GABA-A receptor on the postsynaptic neuron. When this happens, the GABA-A receptor changes shape â€“ thereby opening a pore in the postsynaptic dendrite. This allows chloride ions, which carry an electric charge, to enter the dendrite. As a result, the charge in postsynaptic dendrite becomes more negative, which makes it more difficult to generate an action potential. This is one of the fundamental processes of learning. Because abnormalities in the levels of GABA have been found in individuals with autism, it is logical to examine whether polymorphisms in GABA receptor genes can contribute to the disorder. GABRA3 has become a candidate gene for autism, but findings have been somewhat mixed.
GABRB3, gaba, receptor, inhibitory, inhibition, neurotransmitter, candidate gene, autism
- ID: 916
- Source: DNALC.G2C
Use this chromosome map to explore genes associated with autism.
An overview of autism-related content on Genes to Cognition Online.
Doctor Josh Dubnau explains that the genes active in different neurons can make them excitatory (e.g. glutamate) or inhibitory (e.g. GABA). These neurotransmitters are critical to learning.
An overview of language-related content on Genes to Cognition Online.
Several lines of research are converging to show how opposing genetic pathways can lead to autism.
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
Gamma-aminobutyric acid (GABA) is a very common neurotransmitter in the Central Nervous System, whose primary function is to inhibit the transmission of a signal through a neuron.
AVPR1A is a candidate gene for autism.
Professor Trevor Robbins describes the GABA (or GABAergic) system, whose main function in the brain is inhibition.
Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.