GABA (Gamma-aminobutyric Acid)

Professor Trevor Robbins describes the GABA (or GABAergic) system, whose main function in the brain is inhibition.

The GABAergic system is one of the two important amino acid systems in the brain. The glutamate system is responsible for fast signaling, for excitation. The GABA system is responsible for fast signaling inhibition. So, it is like the off switch in an electrical network, it responds very quickly. The cortex, the neocortex and the hippocampus are made up of networks of neurons which work by on and off switches, by glutamate and GABAergic neurons. So, GABA is a very interesting neurotransmitter because drugs such as the benzodiazepines or Liprium work by affecting GABA. They enhance GABAergic function and hence produce anxiolysis or anxiety reduction.

GABA, GABAergic, inhibition, neurotransmitter, Benzodiapins, Liprium, neocortex, hippocampus, neurons, cortex, brain, anxiolysis, anxiety, trevor, robbins,

Related Content

811. The Glutamate System

Professor Trevor Robbins describes some of the key functions of the excitatory glutamate system, which is integral to information processing and long-term potentiation.

  • ID: 1151
  • Type:
  • Source: G2C

1147. The Noradrenaline (Norepinephrine) System

Professor Trevor Robbins describes the noradrenaline system, which is highly involved in arousal.

  • ID: 1151
  • Type:
  • Source: G2C

1439. Biochemicals - Excitation and Inhibition

Doctor Josh Dubnau explains that the genes active in different neurons can make them excitatory (e.g. glutamate) or inhibitory (e.g. GABA). These neurotransmitters are critical to learning.

  • ID: 1151
  • Type:
  • Source: G2C

813. The Serotonergic System

Serotonin is a neurotransmitter associated with a number of cognitive disorders, namely depression, bipolar and schizophrenia. Professor Trevor Robbins explains how the serotoninergic system works.

  • ID: 1151
  • Type:
  • Source: G2C

1154. Basal Ganglia - Primary Functions

Professor Trevor Robbins discusses the function of a set of structures called the basal ganglia, which seem to be involved in response selection.

  • ID: 1151
  • Type:
  • Source: G2C

1150. Acetylcholine and the Cholinergic System

Professor Trevor Robbins discusses two functions of the cholinergic (acetylcholine) system. One is involved in arousal and memory, the other in the sleep/waking cycle.

  • ID: 1151
  • Type:
  • Source: G2C

916. GABRB3 Gene

GABA is the main inhibitory neurotransmitter in the adult brain. GABRA3 is a candidate gene for autism.

  • ID: 1151
  • Type:
  • Source: G2C

812. The Dopamine System

Professor Trevor Robbins explains that the dopamine system is a group of cells originating in the midbrain whose function may be to prepare the brain to think, move, and anticipate rewards.

  • ID: 1151
  • Type:
  • Source: G2C

1199. ADHD - Noradrenaline and Dopamine

Professor Trevor Robbins discusses ADHD in relation to noradrenaline and dopamine, both of which are enhanced by ADHD medications such as Ritalin.

  • ID: 1151
  • Type:
  • Source: G2C

485. GABA Neurotransmitter

Gamma-aminobutyric acid (GABA) is a very common neurotransmitter in the Central Nervous System, whose primary function is to inhibit the transmission of a signal through a neuron.

  • ID: 1151
  • Type:
  • Source: G2C