Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.
Metabotropic Glutamate Receptor-3 (GRM3) is a G-protein coupled receptor for glutamate, a major excitatory neurotransmitter. GRM3 also modulates serotonin and dopamine transmission. Several association studies have linked GRM3 polymorphisms to schizophrenia, suggesting functional changes in glutamate transmission in the prefrontal cortex and hippocampus.
schizophrenia, gene, candidate, GRM3, grm, metabotropic, glutamate, Receptor-3, g protein coupled receptor, g protein, dopamine, cyclic amp, c-amp, camp, guanine, polymorphisms, gtp
- ID: 510
- Source: DNALC.G2C
An interactive chromosome map of the genes and loci associated with schizophrenia.
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An interactive chromosome map of the genes and loci associated with learning and memory.
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Professor Daniel Weinberger discusses evidence from a number of research areas that highlight the importance of the neurotransmitter glutamate in schizophrenia.
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