CAMP Signaling Network
Doctor Josh Dubnau explains that the cyclic AMP (cAMP) signaling network can receive signals from outside the cell and use the signal to alter the function of the cell.
The cyclic AMP signaling network is one example of a signaling network that has the property that it allows neurons to receive signals from outside the cell, and transmit that either locally to proteins that already exist and to alter their function, or to signal into the nucleus and tell the neuron itâ€™s time to make a group of new proteins and deliver them out into the cell to alter the function of the cell.
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Doctor Josh Dubnau explains that the function of signaling networks is to receive signals from outside the cell, and transmit that information into the cell, in some cases to the nucleus.
Regulator of G-Protein Signaling 4 (RGS4) is a candidate gene for schizophrenia.
Doctor Josh Dubnau explains that the genes active in different neurons can make them excitatory (e.g. glutamate) or inhibitory (e.g. GABA). These neurotransmitters are critical to learning.
The cAMP response element-binding protein 1 (CREB1) gene is a CREB activator and has been found to facilitate long-term memory formation.
Doctor Josh Dubnau explains that some genes are preferentially active in one part of the brain or body, while other genes are particular active in another location.
CAMP response element-binding protein 2(CREB2) is also known as Activating Transcription Factor 2 (ATF2). CREB2 is a CREB repressor, which means it inhibits long-term memory formation.
Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) is a candidate gene for schizophrenia.
Doctor Josh Dubnau explains that memories result from rapid changes in the connections in a huge network of neurons. We do not know, however, the precise mechanism driving these changes.
Doctor Josh Dubnau describes learning as a change in an animal’s behavior in response to previous stimuli or experience.
Doctor Josh Dubnau explains that genes are responsible for memory in that they contain the raw instructions for memory. Experience determines how these instructions are assembled.