Polymorphisms of DAOA are associated with schizophrenia and bipolar disorder risk.
D-Amino Acid Oxidase Activator (DAOA) is found in peroxisomes where it triggers the degradation of the gliotransmitter D-serine, which is a strong activator of NMDA-type glutamate receptors. Increased activity of DAOA could reduce D-serine and NMDA receptor functioning. DAOA overlaps and shares a complementary chromosomal strand with G72. Polymorphisms of DAOA and G72 are associated with schizophrenia risk and diminished prefrontal and hippocampal function. A 2003 study by Hattori and colleagues also identified the DAOA/G72 as a strong candidate site for bipolar disorder although researchers have yet to identify a causal polymorphism.
gene, schizophrenia, schizophrenic, D-Amino, Oxidase, Activator, DAOA, peroxisome, gliotransmitter, D-serine, NMDA, glutamate, receptors, G72, prefrontal, pfc, hippocampal, hippocampus
- ID: 923
- Source: DNALC.G2C
An interactive chromosome map of the genes and loci associated with schizophrenia.
Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.
Professor Daniel Weinberger explains that the schizophrenia candidate gene, COMT, is abundantly expressed in the hippocampus and prefrontal cortex.
An overview of bipolar disorder-related content on Genes to Cognition Online.
Professor Daniel Weinberger discusses evidence from a number of research areas that highlight the importance of the neurotransmitter glutamate in schizophrenia.
Increased neuregulin signaling in schizophrenia may suppress the NMDA receptor, leading to lowered glutamate levels.
An overview of schizophrenia-related content on Genes to Cognition Online.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.