Professor Daniel Weinberger explains that the schizophrenia candidate gene, COMT, is abundantly expressed in the hippocampus and prefrontal cortex.
Where is COMT expressed? So COMT is a gene that is turned on and off by the activity of a cell. And the cells that happen to have a lot of COMT in them are particularly the cells of the regions of the brain that are most implicated in schizophrenia - the prefrontal cortex and the hippocampal formation. And so nerve cells, neurons in these two parts of the brain, express, particularly abundantly, COMT.
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Professor Daniel Weinberger discusses evidence from a number of areas of research that marks COMT as a candidate gene for schizophrenia.
Professor Daniel Weinberger discusses evidence from a number of research areas that highlight the importance of the neurotransmitter glutamate in schizophrenia.
An overview of schizophrenia-related content on Genes to Cognition Online.
Professor Daniel Weinberger explains why the gene COMT, which detoxifies dopamine, is a candidate gene for schizophrenia.
Professor Daniel Weinberger discusses research that makes dysbindin a candidate gene for schizophrenia.
Professor Daniel Weinberger explains that the frontal lobes, which are involved in planning and reasoning, may be disrupted in schizophrenia.
The frontal lobe is part of the cerebral cortex and is the largest of the brain's structures. It is the main site of so–called 'higher' cognitive functions.
Professor Daniel Weinberger describes how neuroimaging techniques are being used to examine the brains of schizophrenic patients.
An interactive chromosome map of the genes and loci associated with schizophrenia.
Low activity of the COMT gene is associated with obsessive-compulsive disorder, as well as schizophrenia.