COMT and Schizophrenia
Professor Daniel Weinberger explains why the gene COMT, which detoxifies dopamine, is a candidate gene for schizophrenia.
COMT is one of the genes that has been studied, rather extensively, as a candidate risk gene for schizophrenia. COMT stands for catechol-O-methyl transferase. The gene encodes a protein, most genes code for proteins, which are enzymes, or various other molecules in cells. They are the machinery of how a cell works and the gene is the blueprint for transcribing this machinery. COMT was discovered by Julie Axelrod at the NIH in 1957 for which he actually won the Nobel Prize. It was the first of a family of these enzymes that inactivated chemicals in the body by methylating them. These were like detoxifying enzymes. And thereâ€™s been a lot of interest in COMT because it detoxifies, among other things, dopamine. And since dopamine is one of the chemicals that has been on the top-ten list of likely culprits in the biology of schizophrenia, the fact that COMT affects dopamine made COMT an appealing gene to look for. And COMT makes dopamine more or less active.
schizophrenia, comt, dopamine, catechol-O-methyl transferase, catechol, methyl transferase, gene, protein, daniel, weinberger
- ID: 1168
- Source: DNALC.G2C
- Download: Theora Video Windows Media Video MPEG 4 Video
924. COMT Gene
Low activity of the COMT gene is associated with obsessive-compulsive disorder, as well as schizophrenia.
1169. COMT expression
Professor Daniel Weinberger explains that the schizophrenia candidate gene, COMT, is abundantly expressed in the hippocampus and prefrontal cortex.
1170. COMT and Schizophrenia Research
Professor Daniel Weinberger discusses evidence from a number of areas of research that marks COMT as a candidate gene for schizophrenia.
1173. Glutamate and Schizophrenia
Professor Daniel Weinberger discusses evidence from a number of research areas that highlight the importance of the neurotransmitter glutamate in schizophrenia.
868. Candidate Genes for Schizophrenia
An interactive chromosome map of the genes and loci associated with schizophrenia.
1165. Dopamine and Schizophrenia
Professor Daniel Weinberger explains that dopamine is the major focus of biochemical research into schizophrenia.
An overview of schizophrenia-related content on Genes to Cognition Online.
1171. Dysbindin and Schizophrenia
Professor Daniel Weinberger discusses research that makes dysbindin a candidate gene for schizophrenia.
1172. Neuregulin and Schizophrenia
Professor Daniel Weinberger discusses research that makes neuregulin a candidate gene for schizophrenia.
471. Chromosome Map of Disorders and Processes
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.