Candidate Genes for Depression
The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.
Advances in genomic technology have added considerable power to the search for genes associated with depression. The irony of these developments is that they paint an increasingly complex picture. The intriguing interplay between genes and environment are at the heart of this complexity, and uncovering these dynamics promises to shed new light on the nature of cognition. In addition to the relatively large contribution of environmental factors to its etiology, the search for candidate genes for depression is further complicated by the fact that the disorder takes many different forms. The genes 5-HTT, BDNF, and TPH2 have attracted much attention in recent years but results linking them to depression have been inconsistent. Recent pharmacogenetics studies have additionally associated FKBP5 and HTR2A with depression, and with response to antidepressants in particular.
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- ID: 1464
- Source: DNALC.G2C
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
The 5-HTT gene has been associated with both depression and autism.
An overview of bipolar disorder-related content on Genes to Cognition Online.
Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.
Because serotonin is critical to so many processes in the central nervous system, genes involved in its synthesis are interesting to neuroscientists.
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
Use this chromosome map to explore genes associated with autism.
Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central nervous system. It has attracted much attention as a depression candidate gene.
Individual variations in antidepressant treatment outcomes.