Candidate Genes for Depression

The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.

Advances in genomic technology have added considerable power to the search for genes associated with depression. The irony of these developments is that they paint an increasingly complex picture. The intriguing interplay between genes and environment are at the heart of this complexity, and uncovering these dynamics promises to shed new light on the nature of cognition. In addition to the relatively large contribution of environmental factors to its etiology, the search for candidate genes for depression is further complicated by the fact that the disorder takes many different forms. The genes 5-HTT, BDNF, and TPH2 have attracted much attention in recent years but results linking them to depression have been inconsistent. Recent pharmacogenetics studies have additionally associated FKBP5 and HTR2A with depression, and with response to antidepressants in particular.

depression, genes, candidate, seotonin, htt, 5-htt, 5-httlpr, bdnf, tph2, fkbp5, htr2a,

  • ID: 1464
  • Source: DNALC.G2C

Related Content

1484. Bipolar Disorder Candidate Genes

While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.

  • ID: 1484
  • Source: G2C

918. 5-HTT Gene

The 5-HTT gene has been associated with both depression and autism.

  • ID: 918
  • Source: G2C

2223. Bipolar disorder

An overview of bipolar disorder-related content on Genes to Cognition Online.

  • ID: 2223
  • Source: G2C

1467. HTR2A Gene

Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.

  • ID: 1467
  • Source: G2C

1468. FKBP5 Gene

  • ID: 1468
  • Source: G2C

1466. TPH2 Gene

Because serotonin is critical to so many processes in the central nervous system, genes involved in its synthesis are interesting to neuroscientists.

  • ID: 1466
  • Source: G2C

471. Chromosome Map of Disorders and Processes

An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.

  • ID: 471
  • Source: G2C

908. Autism Candidate Genes

Use this chromosome map to explore genes associated with autism.

  • ID: 908
  • Source: G2C

1465. BDNF Gene

Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central nervous system. It has attracted much attention as a depression candidate gene.

  • ID: 1465
  • Source: G2C

847. Treating Depression

Individual variations in antidepressant treatment outcomes.

  • ID: 847
  • Source: G2C