FK506-binding protein 5 (FKBP5) is an immunophilin protein, which means it plays a role in regulating the immune system. FKBP5 is not preferentially expressed in the brain but has been identified as a candidate gene for major depressive disorder because it seems to interact with the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis is a complex biological mechanism that controls the bodyâ€™s reaction to stress. It is strongly linked to the neurophysiology of depression. Binder and colleagues (2004) found that a functional polymorphism of FKBP5 correlated significantly with the response of depressed patients to antidepressants. Individuals with this polymorphism showed less HPA axis hyperactivity (a hallmark of major depression) during the depressive episode.
depression, candidate, gene, FK506 binding protein 5, FKBP5, immunophilin, g protein, hpa, hypothalamic, pituitary, adrenal, axis,
- ID: 1468
- Source: DNALC.G2C
1983. The HPA axis
Professor James Potash explains that the HPA (hypothalamic pituitary adrenal) axis is the system that control the stress response. The hormone cortisol is intrinsic to this system.
1464. Candidate Genes for Depression
The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.
511. RGS4 Gene
Regulator of G-Protein Signaling 4 (RGS4) is a candidate gene for schizophrenia.
1467. HTR2A Gene
Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.
2206. Endocrine system - functions
Professor Bruce McEwen describes some of the key players in the endocrine system - hypothalamus, pituitary gland, adrenal cortex, sex glands, and hormones.
2223. Bipolar disorder
An overview of bipolar disorder-related content on Genes to Cognition Online.
510. GRM3 Gene
Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.
868. Candidate Genes for Schizophrenia
An interactive chromosome map of the genes and loci associated with schizophrenia.
825. A Brain Built for Fair Play
A new theory of the neuroscientific basis for the human instinct for fair play.
1982. The diathesis-stress model and bipolar disorder
Professor James Potash describes how the diathesis-stress model can be used to understand interactions between genes and the environment. He refers specifically to bipolar disorder.