The dopamine transporter gene (DAT1/SLC6A3) is a membrane-spanning protein that mediates the reuptake of dopamine from the synapse. It has been associated with bipolar disorder and ADHD.
The dopamine active transporter 1 gene (DAT1, also known as SLC6A3) is a membrane-spanning protein that mediates the reuptake of dopamine from the synapse. DAT1 is the primary regulator of dopamine neurotransmission and is expressed in the central nervous system, primarily in brain areas that make up the dopaminergic circuits (e.g. striatum and nucleus accumbens). DAT1 contains variable number tandem repeats (VNTRs), locations in the genome where a short nucleotide sequence is repeated a number of times. Different individuals can have a different number of repeats, which can cause the gene to behave differently (e.g. produce more or less protein). In a 1995 study, Cook and colleagues found that a 480-bp DAT1 VNTR allele was preferentially transmitted to individuals with ADHD. VNTRs in DAT1 have also been found to associate with bipolar disorder and response to antidepressants (e.g. Kirchheiner and colleagues, 2007).
adhd, bipolar, candidate, gene, DAT1, SLC6A3, dopamine transporter, vntr, variable, number, tandem, repeat, reuptake, striatum, nucleus accumbens
- ID: 1483
- Source: DNALC.G2C
1484. Bipolar Disorder Candidate Genes
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
2397. Dopamine Transporter Networks
Doctor Randy Blakely discusses the potential role of the dopamine transporter (DAT) as one element of a complex protein network in ADHD and bipolar disorder.
An overview of ADHD-related content on Genes to Cognition Online.
An overview of attention-related content on Genes to Cognition Online.
2396. Dopamine Transporters - ADHD, Bipolar, and Schizophrenia
Doctor Randy Blakely discusses the association between the dopamine transporter and ADHD, and discusses a possible relationship with bipolar disorder and schizophrenia.
908. Autism Candidate Genes
Use this chromosome map to explore genes associated with autism.
879. Background to ADHD
All children have occasional trouble paying attention or suppressing their impulses. ADHD is a chronic condition, however, and its main symptoms have a larger effect on people’s lives.
2223. Bipolar disorder
An overview of bipolar disorder-related content on Genes to Cognition Online.
812. The Dopamine System
Professor Trevor Robbins explains that the dopamine system is a group of cells originating in the midbrain whose function may be to prepare the brain to think, move, and anticipate rewards.
2331. Altered BDNF and Dopamine Levels In Depression
Doctor Abraham Zangen point out that dopamine and BDNF levels in the nucleus accumbens and hippocampus of depressed patients are different. Treatment with antidepressants or ECT can impact these differences.