Schizophrenia and Bipolar Disorder - Similar Genetics
Doctor Ellen Leibenluft discusses the similarities between schizophrenia and bipolar disorder, which have some genetic risk factors in common.
There is some evidence that schizophrenia and bipolar disorder, these two illnesses, share some genes of risk. So for example, some of the same genes that have been shown to be abnormal or appear to be abnormal in people with schizophrenia may also abnormal in people with bipolar disorder. We don't know exactly why that is. Of course, both of these illnesses are characterized by psychosis. People with schizophrenia have psychosis, they have hallucinations, they have delusions and people with bipolar disorder can also have psychosis either when they are depressed or when they're manic. One of the things that people are becoming increasingly aware of is the fact that we probably don't inherit risk for schizophrenia per se or bipolar disorder per se. You probably inherit the risk for psychosis, for example. That might explain why these two illnesses, which share some genetic risk, would have some genetic risk factors in common.
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Doctor Ellen Leibenluft discusses some of the biochemicals that have been associated with bipolar disorder, including dopamine, serotonin, and glutamate.
An overview of bipolar disorder-related content on Genes to Cognition Online.
Professor David Lewis discusses the differences between schizophrenia and bipolar disorder, noting that there here may be some shared risk factors.
An overview of schizophrenia-related content on Genes to Cognition Online.
Doctor Ellen Leibenluft explains that there is no one gene for bipolar disorder. Instead, what we have what are called genes of small effect.
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
Doctor Ellen Leibenluft explains that women and men are equally likely to develop bipolar disorder. Women are, however, more likely to develop the disorder after giving birth.
Doctor Ellen Leibenluft explains that although individuals with bipolar disorder can have trouble interpreting emotional expressions, this is much more subtle than in autism.
A review of the causes, symptoms, and treatments of schizophrenia.
Doctor Anil Malhotra discusses the search for genes in both bipolar disorder and schizophrenia, both of which are in their infancy.