Mark Skolnick is a geneticist who was involved in early genetic linkage studies involving Mormons. In 1990, he formed a company called Myriad Genetics to use the power of the Mormon family history and pedigrees to help map and clone genes. Myriad's first target was a breast cancer gene (BRCA1). In 1994, a group from Myriad and their collaborators announced that they located a strong candidate for BRCA1. Their patent on this gene was granted in 1997. Although they were not the first to find the second breast cancer gene (BRCA2), Myriad was the first to isolate it. They patented BRCA2 in 2001. (DNAi location: Applications > Genes and Medicine > Gene hunting > Mark Skolnick)
genetic linkage studies,mormon family history,breast cancer gene,myriad genetics inc,clone genes,breast cancer,skolnick,brca1,location applications,target,geneticist,pedigrees,mormons,collaborators,patent,hunting,medicine
- ID: 15718
- Source: DNALC.DNAi
Mark Skolnick talks about taking advantage of the well-documented genealogy of the Mormon pioneers to study inherited genetic disorders.
Mark Skolnick talks about moving on after the discovery of BRCA1 to find and clone another gene associated with breast cancer, BRCA2.
Mark Skolnick talks about forming a company to discover genes and develop genetic tests.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.
Mark Skolnick talks about the hunt for BRCA1.
Mark Skolnick recounts the complicated process of verifying that the gene they had found was indeed BRCA1.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Mark Skolnick discusses how luck was a major element that helped his team win the race to find and clone BRCA1.
Mary-Claire King talks about testing for breast cancer.
Barbara Weber talks about how she had discovered information that could be useful to families afflicted with hereditary breast cancer even before the gene was found.