Messenger RNA, Matthew Meselson
Interviewee: Matt Meselson. Matt Meselson also had a hand in Sydney Brenner's RNA experiment. He talks about the experiment and how they waited for James Watson's group to finished their RNA work before publishing. (DNAi Location: Code > Copying the code > Players > Matt Meselson > Messenger RNA experiment)
The experiment that had been designed by Francois and Sydney was just the right experiment to ask if there was another kind of RNA on the ribosomes, we knew the ribosomes were the site of protein synthesis, something other than their own RNA, namely the messenger, that was short-lived and so we did that experiment. Meanwhile, Jim and Francois Gros and Howard Hyatt and Curland and a bunch of other people were doing another kind of experiment to detect ribos... messenger RNA here at Harvard. And we finished I think a few months ahead, and so Jim asked us to wait and we did, our papers were published in the very same issue of Nature, I think it was in May 1961.
matthew meselson,site of protein synthesis,rna work,rna transcription,sydney brenner,messenger rna,francois jacob,watson james,james watson,jim watson,curland,ribosomes,dnai,location code,interviewee,mrna,hyatt,harvard,translation
François Jacob, Sydney Brenner and Matt Meselson worked on the role of mRNA. An on/off switch involving mRNA seemed a logical control point for protein production.
Sydney Brenner talks about James Watson's work on RNA.
James Watson talks about the Central Dogma: transcription and translation.
Sydney Brenner showed that mRNA was the unstable intermediate that carried the message from DNA to the ribosomes.
Francis Crick describes RNA and its role and Paul Zamecnick explains protein synthesis.
James Watson talks about RNA's role in the cell.
Sydney Brenner, François Jacob and Matt Meselson's experiment showed that RNA was a copy of the information in DNA. As a messenger, RNA transported the information from the nucleus to the protein-making machinery in the cell.
In this first of a two-part clip, Sydney Brenner describes the information transfer problem from DNA to the protein-making machinery.
The Central Dogma is the flow of genetic information from DNA, to RNA, to protein.
François Jacob talks about how he and Jacques Monod named messenger RNA.