RNA's role in the cell, James Watson
Interviewee: James Watson. After solving the structure of DNA, James Watson started working on RNA. He talks about what he thought of RNA and its function. (DNAi Location: Code > Copying the code > Players > James Watson and Francis Crick > What does RNA do?)
I jokingly used to say, well it was either the template for protein synthesis or it was there to control the viscosity of a cell. Now the latter was a private joke between Francis and I, 'cause he'd spent several years measuring the viscosity of cells, something for which I think he later realized was a total waste of time. So I said it's a template. So when we had the double helix and realized how information in DNA was copied, then I thought, well you could transfer information from a DNA molecule to an RNA, you would separate the DNA strands, but instead of making another DNA strand on it, you'd make an RNA strand.
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James Watson talks about the Central Dogma: transcription and translation.
1953 picture of Francis Crick (L) and James Watson (R) walking along the backs of King's College in Cambridge.
James Watson and Francis Crick developed the idea to explain how DNA and RNA related in protein production.
The structure of DNA, that Watson and Crick discovered, suggests how genetic information is passed on.
Reverse transcription is found in retroviruses.
James Watson and Francis Crick solved the structure of DNA. Other scientists, like Rosalind Franklin and Maurice Wilkins, also contributed to this discovery.
Although the chemistry was wrong, Linus Pauling's triple-stranded DNA model was a catalyst for James Watson and Francis Crick to solve the structure of DNA.
DNA base pairs
Francis Crick describes RNA and its role and Paul Zamecnick explains protein synthesis.
Transcription factors bind to DNA, RNA polymerase begins transcribing messanger RNA (mRNA) molecule from DNA.