The Central Dogma: transcription and translation, James Watson
Interviewee: James Watson. James Watson defines the Central Dogma. (DNAi Location: Code > Copying the code > players > James Watson and Francis Crick > The Central Dogma)
Of course Francis and I talked about protein synthesis and there was evidence that protein synthesis occurred in the cytoplasm of cells, not in the nucleus, so protein synthesis occurred removed from the chromosomes, or seemingly removed from the chromosomes, it occurred on particles which contained RNA. So I thought there must be some system by which the information is transferred from DNA to RNA and then RNA provides the information, is the direct template for protein synthesis. I wrote that on a little piece of paper and taped it above my desk.
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James Watson talks about RNA's role in the cell.
James Watson and Francis Crick developed the idea to explain how DNA and RNA related in protein production.
The Central Dogma is the flow of genetic information from DNA, to RNA, to protein.
1953 picture of Francis Crick (L) and James Watson (R) walking along the backs of King's College in Cambridge.
James Watson and Francis Crick solved the structure of DNA. Other scientists, like Rosalind Franklin and Maurice Wilkins, also contributed to this discovery.
Because it contains the directions for assembling the components of the cell, DNA is often thought of as the "instruction book" for assembling life.
Francis Crick describes RNA and its role and Paul Zamecnick explains protein synthesis.
James Watson and Francis Crick, Cambridge University, 1953
James Watson talks about how he and Francis Crick decided whose name went first on the 1953 paper.
RNA is an intermediary between DNA and protein.