Doctor Thomas Nuhse explains that phosphorylation is the process by which a phosphate is added to a protein to produce a change in that protein.
Phosphorylation is essentially a way of decorating a protein by adding a phosphate onto it, and this phosphorylation does one of many different things. It could mean either that the protein becomes more active or less active, it could mean that it starts working together with another protein, it could mean that it becomes less stable in the cell or more stable or it could mean that it goes to a different place in the cell.
phosphate, protein, phosphorylation, cell, stability
Professor Tom O'Dell defines phosphorylation - the addition of a phosphate group to a protein molecule to regulate gene function.
Doctor Thomas Nuhse explains that kinases are enzymes that are specialized for attaching a phosphate group to another protein.
Professor Donna Wilcock describes neurofibrillary tangles, which form inside the neuron in Alzheimer's disease and are composed of tau proteins.
Professor Tom O'Dell comments that phosphorylation plays a crucial role in synaptic plasticity.
Doctor Thomas Nuhse describes the process by which proteins interact and work together to produce an outcome.
Professor Karim Nader explains that consolidation is a theory of memory that attributes memory formation to changes in synaptic strength and efficiency.
Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) is a candidate gene for schizophrenia.
In this section learn that many signaling pathways ultimately pass messages to the nucleus of a cell.
Signal transduction is cell communication that involves a series of molecular transformations.
Doctor Brian Bacskai discusses what a tangle is and how it leads to death of neurons.