Protein-protein Interactions

Doctor Thomas Nuhse describes the process by which proteins interact and work together to produce an outcome.

Many proteins only work together with other proteins. The reason for that is, for example, to regulate the activity of one protein. One protein might be an enzyme - it might cleave something in two or add, for example, a phosphate to another protein if it is a kinase. Quite often the kinase doesn’t know when and where it should be active - where it should sit in the cell, which other proteins it should add that phosphate onto. And quite often then kinases work together with other proteins in what we call a protein-protein interaction to specify where the activity of the first protein should happen.

protein, interactions, kinase, phosphate, proteins

Related Content

1300. Kinases

Doctor Thomas Nuhse explains that kinases are enzymes that are specialized for attaching a phosphate group to another protein.

  • ID: 1300
  • Source: G2C

1021. Pathways, To the nucleus

In this section learn that many signaling pathways ultimately pass messages to the nucleus of a cell.

  • ID: 1021
  • Source: IC

1022. Pathways, Inside the nucleus

In this section learn that an activated protein is transported into the nucleus through a pore in the nuclear membrane.

  • ID: 1022
  • Source: IC

1020. Pathways, A bevy of interactions

In this section learn that receptors activate each other before binding an adaptor molecule and an exchange factor.

  • ID: 1020
  • Source: IC

1105. Phosphorylation

Professor Tom O'Dell defines phosphorylation - the addition of a phosphate group to a protein molecule to regulate gene function.

  • ID: 1105
  • Source: G2C

1019. Pathways, Beneath the membrane

In this section learn that the binding of growth factors outside the cell causes receptors ends to intertwine and activate each other, and once active, the modified receptor ends interact with messenger proteins.

  • ID: 1019
  • Source: IC

1277. Molecules for Memory

Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.

  • ID: 1277
  • Source: G2C

509. PPP1R1B Gene

Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) is a candidate gene for schizophrenia.

  • ID: 509
  • Source: G2C

1024. Pathways, Releasing the protein

In this section learn that newly made proteins leave the endoplasmic reticulum wrapped in a layer of membrane called a vesicle.

  • ID: 1024
  • Source: IC

1302. Phosphorylation

Doctor Thomas Nuhse explains that phosphorylation is the process by which a phosphate is added to a protein to produce a change in that protein.

  • ID: 1302
  • Source: G2C