Doctor Thomas Nuhse describes the process by which proteins interact and work together to produce an outcome.
Many proteins only work together with other proteins. The reason for that is, for example, to regulate the activity of one protein. One protein might be an enzyme - it might cleave something in two or add, for example, a phosphate to another protein if it is a kinase. Quite often the kinase doesnâ€™t know when and where it should be active - where it should sit in the cell, which other proteins it should add that phosphate onto. And quite often then kinases work together with other proteins in what we call a protein-protein interaction to specify where the activity of the first protein should happen.
protein, interactions, kinase, phosphate, proteins
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Doctor Thomas Nuhse explains that kinases are enzymes that are specialized for attaching a phosphate group to another protein.
1021. Pathways, To the nucleus
In this section learn that many signaling pathways ultimately pass messages to the nucleus of a cell.
1022. Pathways, Inside the nucleus
In this section learn that an activated protein is transported into the nucleus through a pore in the nuclear membrane.
1020. Pathways, A bevy of interactions
In this section learn that receptors activate each other before binding an adaptor molecule and an exchange factor.
Professor Tom O'Dell defines phosphorylation - the addition of a phosphate group to a protein molecule to regulate gene function.
1019. Pathways, Beneath the membrane
In this section learn that the binding of growth factors outside the cell causes receptors ends to intertwine and activate each other, and once active, the modified receptor ends interact with messenger proteins.
1277. Molecules for Memory
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.
509. PPP1R1B Gene
Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) is a candidate gene for schizophrenia.
1024. Pathways, Releasing the protein
In this section learn that newly made proteins leave the endoplasmic reticulum wrapped in a layer of membrane called a vesicle.
Doctor Thomas Nuhse explains that phosphorylation is the process by which a phosphate is added to a protein to produce a change in that protein.