Executive Errors in Schizophrenia
Professor David Lewis outlines a major cognitive symptom of schizophrenia, which is executive dysfunction - an inability to exert control over behavior.
In addition to positive symptoms and negative symptoms, one of the core features of schizophrenia are disturbances in cognitive processes. One type of cognitive process that seems to be commonly disturbed in the illness is so called executive processes, which basically represent the ability to exert control over thought and behavior. A typical example of this is the ability to inhibit what might be called a prepotent or preprogrammed response. Individuals with schizophrenia seem to be impaired in that ability. Another area of cognitive control is the ability to be given a small bit of information, transiently keep it in mind, and manipulate it in order to guide thought or behavior. So, an example of that would be being given a phone number to remember, then using that information to go and place the phone call, and to be able to keep that information in mind in order to execute the behavior. Individuals with schizophrenia tend to have disturbances in, not specifically the ability to make a phone call, but in the ability to transiently maintain and manipulate information in order to guide their thought logically, their speech logically, and to perform in a way that is appropriate for their environment.
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Professor David Lewis discusses how the diversity of symptoms in schizophrenia is reflected in the diversity of genetic and neural causes of the disorder.
Professor David Lewis explains that schizophrenic individuals can have coordination problems, which may relate to impaired neural circuits.
Professor David Lewis explains that positive symptoms of schizophrenia are currently more treatable than the negative symptoms.
An overview of schizophrenia-related content on Genes to Cognition Online.
Professor David Lewis explains that the symptoms of schizophrenia are typically defined as either positive or negative.
Professor Trevor Robbins explains that the prefrontal cortex is involved in executive functions such as planning and decision-making.
Professor David Lewis explains that although many symptoms of schizophrenia are not reproducible in animals, animal models can help understand the disorder.
Professor David Lewis discusses the differences between schizophrenia and bipolar disorder, noting that there here may be some shared risk factors.
Professor David Lewis explains the difference between first and second generation drug treatments for schizophrenia.
An overview of thinking-related content on Genes to Cognition Online.